Check out our review article in Current Opinion in Neurobiology, examining the relationship between sleep, the E/I ratio, and autism spectrum disorder:

Bridi MCD, Peixoto L.  Excitatory/inhibitory imbalance as a mechanism linking autism and sleep problems.  Curr Opin Neurobiol.  2025.  90:102968.  doi: 10.1016/j.conb.2024.102968. 

Check out our latest study in iScience, showing that sleep-dependent patterns of E/I regulation are altered in two mouse models of ASD:

Bridi MCD, Luo N, Kim G, Menarchek BJ, Lee RA, Rodriguez B, Severin D, Wesselborg C, O’Ferrall C, Patel R, Bertrand S, Kannan S, Kirkwood A. Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism.  iScience. 2025.  28(2):111917.  doi: 10.1016/j.isci.2025.111917.

Check out our latest publication in the Journal of Neuroscience, showing that both early closed eye depression and late open eye potentiation rely on GluN2B-containing NMDA receptors during ocular dominance plasticity:

Bridi MCD, Hong S, Severin D, Moreno C, Contreras A, Kirkwood A. Blockade of GluN2B-Containing NMDA Receptors Prevents Potentiation and Depression of Responses during Ocular Dominance Plasticity. J Neurosci. 2024 Sep 4;44(36). doi: 10.1523/JNEUROSCI.0021-23.2024

Graduate student Bryan Rodriguez received a fellowship from the WV Space Grant Consortium, supported by the National Science Foundation.  Congratulations, Bryan!

Bryan passed his preliminary exam and is now officially a doctoral candidate!  Congratulations, Bryan!

Dr. Bridi received a Young Investigator award from the Brain & Behavior Research Foundation to study the relationship between sleep and the E/I ratio in a mouse model of schizophrenia.

Check out our new preprint, available on BioRxiv: GluN2B-containing NMDA receptors are required for potentiation and depression of responses in ocular dominance plasticity.

The lab officially opened September 2022!  I am excited to be working jointly with Morgan Bridi to get our labs up and running.  We are located in the Rockefeller Neuroscience Institute on the WVU Health Sciences campus--stop by for a visit!